Pharmacodynamics/Pharmacokinetics Search -- EMBASE headings and keywords

Below, I've pasted an EMBASE strategy for a relatively thorough, but not exhaustive, search for articles focused on pharmacodynamic or pharmacokinetic properties of an antiretroviral agent.  I'm posting this here to avoid having to start composing a  pharmacodyanmics/pharmacokinetics concept search from scratch in the future.  I'm sure the search is flawed.  

(drug subject headings or title words) AND ('virus load'/exp OR 'viral load testing'/exp OR 'cd4+ t lymphocyte'/exp OR 'pharmacodynamics'/exp OR 'pharmacokinetics'/exp OR 'pharmacokinetic parameters'/exp OR 'pharmacokinetic assay'/exp OR 'pharmacokinetic modeling software'/exp OR 'pharmacodynamic parameters'/exp OR (((excret* OR eliminat* OR clearance*) NEAR/5 (urin* OR bile OR biliary OR sweat OR saliva* OR exhal* OR tears OR 'breast milk')):ab,ti) OR (((food OR herb OR alcohol OR caffeine OR drug* OR dna) NEAR/5 interact*):ab,ti) OR (((virus OR viral OR virologic*) NEAR/5 respons*):ab,ti) OR ((duration NEAR/5 effect*):ab,ti) OR ((gene NEAR/5 regulat*):ab,ti) OR ((intracellular NEAR/5 signal*):ab,ti) OR ((phenotyp* NEAR/4 chang*):ab,ti) OR ((receptor NEAR/5 densit*):ab,ti) OR ((route* NEAR/5 admin*):ab,ti) OR ((cyp* NEAR/5 (enzym* OR isoenzym*)):ab,ti) OR (((dose OR dosage OR concentration OR level) NEAR/5 (effect* OR response OR activity OR scheme OR protocol OR dependence OR 'kidney function' OR 'renal function' OR 'liver function' OR 'hepatic function')):ab,ti) OR ((('cd4 count*' OR 'cd4 cell count*' OR 'cd4 lymphocyte count*' OR 'hiv-1 rna' OR 'viral load' OR absor* OR accumulat* OR acetylation OR activat* OR 'active secretion*' OR 'active transport*' OR activity OR adh OR adsorp* OR affinity OR agonist* OR 'alcohol dehydrogenase' OR 'aldehyde dehydrogenase' OR aldh OR antagon* OR antiporter* OR aquaporin* OR 'area under the curve' OR 'association constant' OR 'atp-binding cassette' OR auc OR auc12 OR 'binding capacity' OR 'binding protein*' OR bioavail* OR bioequiv* OR biostatic OR biotransform* OR block* OR 'blood-brain barrier*' OR c0 OR 'capacity limited' OR carcinogenic* OR carrier* OR 'catechol-o-methyl transferase' OR 'ceiling effect' OR chronopharmacokin* OR 'circulation time' OR cl OR 'clathrin coated' OR clearance OR 'coated pit*' OR 'coated vesicle*' OR 'coenzyme nicotinamde adenine dinucleotide phosphate' OR compartment* OR competit* OR 'complex formation' OR comt OR 'concentration index' OR 'concentration response' OR 'concentration-time curve*' OR conjugat* OR 'context-sensitive' OR cotransporter* OR 'cross reactivity' OR 'curative dose' OR cytochrome* OR cytotoxic* OR degrad* OR dehalogenat* OR 'delayed release' OR 'depressor response*' OR detoxif* OR dialysab* OR diffus* OR 'dihydropyrimidine dehydrogenase' OR disintegrat* OR disposition* OR dissociat* OR dissolution OR distribut* OR dpd OR 'drug action*' OR 'drug drug' OR 'dt diaphorase' OR dynamin OR 'ec50' OR 'efficacy parameter*' OR 'electrochemical gradient*' OR eliminat* OR emax OR 'enantiomeric ratio' OR endocyt* OR endosome* OR 'enteric coat*' OR enterohepatic OR 'enzyme induction' OR equilibr* OR excret* OR exhanger* OR exocyt* OR 'extracellular fluid' OR 'extracellular space*' OR 'extracellular water' OR filtered OR filtration OR 'first order' OR 'first pass' OR flavoprotein* OR formulat* OR 'gastrointestinal secretion*' OR germistatic OR gi50 OR gi90 OR 'glomerular filtration' OR glucoronid* OR 'glutathione-s-transferase' OR 'glycine conjugation' OR gradient* OR 'growth inhibition' OR gst OR 'half life' OR 'half-time' OR 'hepatic availability' OR 'hepatic enzyme*' OR 'hepatic microsome*' OR 'histamine methyltransferase' OR hmt OR hormesis OR hydroly* OR hydroxylat* OR ic10 OR ic20 OR ic25 OR ic50 OR ic90 OR ic95 OR id50 OR inactivat* OR inducer* OR inhibit* OR inhibit* OR 'inhibitory concentration' OR 'interpatient variation' OR 'interstitial fluid*' OR 'intersubject variation' OR 'intestinal availability' OR intoxicat* OR 'intrinsic activity' OR ionis* OR ioniz* OR iontophor* OR ke OR kinetic* OR 'lipid/water partition' OR lipophil* OR 'liver microsome*' OR 'loading dose' OR 'maintenance dose' OR 'margin of safety' OR 'maximum binding' OR 'maximum effect' OR 'maximum plasma concentration' OR 'maximum possible effect' OR mechanism OR metabol* OR methylat* OR mic OR mic50 OR mic80 OR mic90 OR microbiocidal OR microbiostatic OR 'minimal inhibitory concentration*' OR 'minimal microbicidal concentration*' OR 'minimum effective concentration*' OR 'minimum effective level*' OR 'minimum inhibitory concentration*' OR 'minimum microbicidal concentration*' OR 'minimum microbicidal concentration*' OR 'minimum plasma concentration*' OR mmc OR 'monoamine oxidase*' OR 'multi-compartment' OR 'n acetyltransferase' OR nadph OR 'nadphr-cytochrome p450' OR noael OR nq01 OR oxidat* OR p450 OR 'paracellular pathway*' OR 'partial response*' OR partition OR 'partition coefficient' OR 'passage rate*' OR peak* OR penetrat* OR permeab* OR ph OR phagocyt* OR pharmacodynam* OR pharmacokin* OR pka OR 'plasma water' OR pore OR pores OR porin OR 'portal circulat*' OR 'portal system' OR potenc* OR potenc* OR potentiat* OR prodrug* OR 'pro drug*' OR 'protein binding' OR 'protein bound' OR 'pulsatile release' OR 'quinone oxidoreductase' OR 'rate of passage' OR reabsor* OR 'reactive metabolite' OR rebound OR receptor* OR redistribut* OR redox OR 'residence time*' OR resistance OR response OR retention OR saturab* OR 'second messenger*' OR selectiv* OR sensitivity OR sequester* OR 'single pass' OR 'site of action' OR 'slow release' OR solub* OR specificity OR 'standardized uptake value' OR 'steady state' OR 'steady state' OR stimulat* OR substrate* OR sulfat* OR sulfotransferase* OR supersensitivity OR suscept* OR 'sustained-release' OR symporter* OR 't ½' OR 't1/2' OR tachyphyla* OR 'target cell*' OR 'target organ*' OR 'target tissue*' OR targeted OR targeting OR 'therapeutic drug monitoring' OR 'therapeutic equivalence' OR 'therapeutic index*' OR 'therapeutic window' OR 'thiopurine methyltransferase' OR 'time to maximum' OR 'timed release' OR 'tissue binding' OR 'tissue depot*' OR 'tissue reservoir*' OR titrat* OR tlovr OR tolerab* OR tolerance OR 'total body water' OR 'toxic concentration' OR 'toxic level*' OR toxic* OR tpmt OR transcellular OR transcyto* OR transform* OR 'transit time*' OR transmembrane OR transport* OR 'trough concentration' OR trough* OR ugt* OR uptake OR 'uridine diphosphate glucuronosyltransferase*' OR virocidal OR virostatic OR 'zero order') NEAR/10 (drug keywords)):ab,ti)) 

Dose-finding studies or reviews discussing same

The search strategies below are just initial attempts to produce search strategies that focus on dose-finding studies.  Proximity searching is very useful for this topic.  Neither of the PubMed strategies below comes close to being comprehensive.

EMBASE:
(dose* OR dosage*) NEAR/4 (find* OR rang* OR escalat* OR 'phase i' OR 'phase 1' OR 'phase 2' OR 'phase ii') NEAR/7 (stud* OR trial* OR group*)

PubMed:
("dose finding" OR "dose escalating" OR "dose escalation" OR "dose ranging")

(dose*[ti] OR dosage*[ti]) AND (find*[ti] OR rang*[ti] OR escalat*[ti] OR "phase 1"[ti] OR "phase i"[ti] OR "phase ii"[ti] OR "phase 2"[ti]) AND (stud* OR trial* OR group*)

Pharmacokinetics -- keywords and MeSH

An initial attempt:
(Pharmacokin* OR pharmacodynam* OR absorb* OR absorption OR "volume of distribution" OR Cmax OR "peak concentration" OR "peak concentrations" OR "peak time" OR "peak times" OR tmax OR AUC OR "area under the curve" OR metabolism OR metabolite* OR "t1/2" OR half-life OR "half life" OR "half lives" OR half-lives OR clearance* OR bioavailab* OR excret* OR "kinetic profile" OR "kinetic profiles" OR compartment* OR "Pharmacokinetics"[Mesh] OR "pharmacokinetics" [Subheading])

An attempt for a different search in EMBASE:

"area under the curve" OR "excretion fraction*" OR "glomerular filtration rate" OR "glomerulus filtration rate" OR  "half life" OR "metabolic stability" OR "protein binding" OR "rate constant*" OR "volume of distribution" OR ((accumulation OR blood-to-plasma OR  enantiomeric OR "standardized uptake" OR metabolic OR partition  OR extraction ) NEAR/3 (ratio OR ratios)) OR ((minimum OR maximum) NEAR/3 concentration) OR ((Unbound OR bound OR protein-bound) NEAR/3 fraction*) OR  (csf OR "cerebrospinal fluid" OR brain) NEAR/3 (plasma OR serum) NEAR/3 (ratio OR ratios) OR (mean NEAR/3 (transit OR residence OR dissolution) NEAR/3 time*) OR (standard* NEAR/3 uptake) OR "uptake value" OR Absorb* OR  Absor* OR  accumulation OR  activation OR  adsor* OR AUC  OR  bioavailability OR Bioequivalence OR Chronopharmacokinetic* OR  clearance OR compartment* OR Cmax OR  dialysability OR  diffusion OR  disposition OR distribution OR egfr OR elimination  OR  excret* OR GFR OR half-life OR half-lives OR  inactivation OR kinetic* OR maternal-fetal OR  metabolic OR  metabolism OR metabolism  OR peak-trough  OR  penetration OR pharmacodynam* OR Pharmacokinetic* OR plasma concentration-time curve OR protein-bound  OR  release OR  retention OR steady-state OR "tablet disintegration" OR "therapeutic equivalence" OR tmax  OR "t1/2"

 

tissue levels (of a drug)

((tissue OR tissues OR penetrat* OR permeat*)  AND (level* OR penetrat* OR permeat* OR concentration* OR pharmacokinetic* OR "pharmacokinetics"[sh])) 

This is a first attempt at this concept.  Suggestions, as always, are welcome.  

Individual tissue names --.e.g. bone, skin, muscle.. -- and tissue adjectives -- e.g. hepatic, osseous, ... -- could be OR'd into the tissue term list.

Urine drug screen

 (urine OR urines OR urinary OR urinalysis OR OR urinalyses OR urinalys*) AND ("drug screen" OR "drug screens" OR "drug screening" OR drug-screen* OR "drug test" OR "drug tests" OR "drug testing" OR drug-test* OR "Substance Abuse Detection/methods"[mesh] OR "substance-related disorders/urine"[mesh] OR "Street Drugs/urine"[mesh])

You may wonder about my reasons for including several terms that would be retrieved by an included truncated term.  My institution recently licensed EMBASE.  Truncation is sometimes rejected in complex EMBASE searches.  I tend to create my basic search with both PubMed and EMBASE in mind.

minimum inhibitory concentration (MIC) -- keywords and MeSH

(MIC OR "Minimum inhibitory concentration" OR "minimum-inhibitory concentration" OR "Minimum inhibitory concentrations" OR "minimum-inhibitory concentrations" OR "Minimal inhibitory concentration" OR "minimal-inhibitory concentration" OR "Minimal inhibitory concentrations" OR "minimal-inhibitory concentrations" OR MICs OR "microbial sensitivity test" OR "microbial sensitivity tests" OR "microbial-sensitivity test" OR "microbial sensitivity test" OR "Antimicrobial Susceptibility" OR "Drug Sensitivity Assay" OR "Drug Sensitivity Assays" OR Antibiogram* OR "bacterial sensitivity test" OR "bacterial-sensitivity test" OR "bacterial sensitivity tests" OR "bacterial-sensitivity tests" OR "Microbial Sensitivity Tests"[Mesh] OR "Inhibitory Concentration 50"[Mesh]) 

8/29/14 - The strategy above has been revised .  Many thanks to Jean-Dominique Pierret, Ph.D.  who suggested that I OR in --
"Minimal inhibitory concentration" OR "minimal-inhibitory concentration" OR "Minimal inhibitory concentrations" OR "minimal-inhibitory concentrations"
 

topical administration -- keywords and mesh

("Administration, Topical"[mesh] OR "Iontophoresis"[Mesh] OR "Ointments"[Mesh] OR "Gels"[Mesh] OR "transdermal patch"[mesh] OR "Mouthwashes"[Mesh] OR "Dentifrices"[Mesh] OR  topical* OR cream* OR ointment* OR salve* OR trans-cutaneous OR transcutaneous OR iontophor* OR Ionto-phor* OR transdermal OR trans-dermal OR unguent* OR paste* OR gel* OR rinse OR swish* OR Mouthwash* OR dentrific* OR toothpast* )

interventions to improve compliance with pharmacologic therapy

These are not comprehensive searches. Rather they are relatively focused searches for articles about interventions designed to improve compliance to drug therapy. I've been asked for similar searches repeatedly and expect to be asked for work on this search topic again in the future. I'm posting these searches so I have a more advanced starting place for my future efforts. If you are aiming at comprehensive retrieval, removing the [ti] tags and changing [majr] to [mesh] would produce a starting point .

MEDLINE:

((("Patient Compliance"[MAJR] OR compliant[ti] OR compliance[ti] OR comply[ti] OR complying[ti] OR complied[ti] OR complies[ti] OR adhere[ti] OR adheres[ti] OR adhering[ti] OR adherent[ti] OR adhered[ti] OR adherence[ti]) and ("drug therapy"[sh] OR drug OR drugs OR medication* OR pharmacolog* OR Pharmacotherap* OR dose OR doses OR doseage* OR dosage* OR dosing OR dosed OR pill OR pills OR capsule OR capsules OR tablet* OR injection* OR injected OR injects OR injecting OR "drug therapy"[majr] )) OR "medication adherence"[mAJR] ) AND (support*[ti] OR patient-support[ti] OR "Social Support"[majr] OR "pharmacist care" OR "pharmaceutical care" OR program[ti] OR intervention*[ti] OR "Outcome and Process Assessment (Health Care)"[majr] OR "Patient Education as Topic/methods"[majr] OR "Community Pharmacy Services"[majr] OR "Persuasive Communication"[majr] OR "Cellular Phone"[majr] OR "Reminder Systems"[majr] OR "motivation"[majr] OR "Monitoring, Ambulatory"[majr] OR "Counseling/methods"[majr] OR "Interviews as Topic/methods"[majr] OR "Deductibles and Coinsurance/economics"[majr] OR "Cost Savings"[majr] OR "Medical Informatics Applications"[majr] OR "Taste"[majr] OR pleasant*[ti] OR palatab*[ti] OR "mobile phone"[ti] OR "mobile phones"[ti] OR "cellular phone"[ti] OR "cellular phones"[ti] OR "cell phone"[ti] OR "cell phones"[ti] OR videophone*[ti] OR "text message"[ti] OR "text messages"[ti] OR "text messaging"[ti] OR "text messaged"[ti] OR reminder*[ti] OR alert[ti] OR alerts[ti] OR alerting[ti] OR alerted[ti] OR message*[ti] OR (single*[ti] AND multiple*[ti] ) OR "avoid discontinuation"[ti] OR "phone calls"[ti] OR "phone call"[ti] OR "copayment reduction"[ti] OR "copayment reductions"[ti] OR "reduced copayments"[ti] OR "reduced copayment"[ti] OR "cut copayments"[ti] OR "copayment cuts"[ti] OR "cut copayment"[ti] OR "copayment cut"[ti] OR "adherence intervention"[ti] OR "compliance intervention"[ti] OR "adherence interventions"[ti] OR "compliance interventions"[ti] OR mailing*[ti] OR motivational[ti] OR "home telemonitoring"[ti] OR strategies[ti] OR strategy[ti] OR (simplif*[ti] AND Regimen*[ti] ) OR "improving adherence"[ti] OR value-based[ti] OR "value based"[ti] OR "disease management"[ti] OR "compliance aid"[ti] OR "compliance aids"[ti] OR "adherence aid"[ti] OR "adherence aids"[ti] OR "addressing nonadherence"[ti] OR "adressing noncompliance"[ti] OR Nudg*[ti] OR coach*[ti] OR engag*[ti] OR DOTS[ti] OR "directly observed"[ti] OR directly-observed[ti] OR "lay health worker"[ti] OR "lay health-worker"[ti] OR newsletter*[ti] OR incentive*[ti] OR assistance[ti] OR counsel*[ti] OR promot*[ti] OR SMS[ti] OR educat*[ti])

PREMEDLINE/OLD MEDLINE/unindexed PMC records

((compliant[ti] OR compliance[ti] OR comply[ti] OR complying[ti] OR complied[ti] OR complies[ti] OR adhere[ti] OR adheres[ti] OR adhering[ti] OR adherent[ti] OR adhered[ti] OR adherence[ti]) and ( drug OR drugs OR medication* OR pharmacolog* OR Pharmacotherap* OR dose OR doses OR doseage* OR dosage* OR dosing OR dosed OR pill OR pills OR capsule OR capsules OR tablet* OR injection* OR injected OR injects OR injecting )) AND (support*[ti] OR patient-support[ti] OR "pharmacist care" OR "pharmaceutical care" OR program[ti] OR intervention*[ti] OR pleasant*[ti] OR palatab*[ti] OR "mobile phone"[ti] OR "mobile phones"[ti] OR "cellular phone"[ti] OR "cellular phones"[ti] OR "cell phone"[ti] OR "cell phones"[ti] OR videophone*[ti] OR "text message"[ti] OR "text messages"[ti] OR "text messaging"[ti] OR "text messaged"[ti] OR reminder*[ti] OR alert[ti] OR alerts[ti] OR alerting[ti] OR alerted[ti] OR message*[ti] OR (single*[ti] AND multiple*[ti] ) OR "avoid discontinuation"[ti] OR "phone calls"[ti] OR "phone call"[ti] OR "copayment reduction"[ti] OR "copayment reductions"[ti] OR "reduced copayments"[ti] OR "reduced copayment"[ti] OR "cut copayments"[ti] OR "copayment cuts"[ti] OR "cut copayment"[ti] OR "copayment cut"[ti] OR "adherence intervention"[ti] OR "compliance intervention"[ti] OR "adherence interventions"[ti] OR "compliance interventions"[ti] OR mailing*[ti] OR motivational[ti] OR "home telemonitoring"[ti] OR strategies[ti] OR strategy[ti] OR (simplif*[ti] AND Regimen*[ti] ) OR "improving adherence"[ti] OR value-based[ti] OR "value based"[ti] OR "disease management"[ti] OR "compliance aid"[ti] OR "compliance aids"[ti] OR "adherence aid"[ti] OR "adherence aids"[ti] OR "addressing nonadherence"[ti] OR "adressing noncompliance"[ti] OR Nudg*[ti] OR coach*[ti] OR engag*[ti] OR DOTS[ti] OR "directly observed"[ti] OR directly-observed[ti] OR "lay health worker"[ti] OR "lay health-worker"[ti] OR newsletter*[ti] OR incentive*[ti] OR assistance[ti] OR counsel*[ti] OR promot*[ti] OR SMS[ti] OR educat*[ti]) NOT MEDLINE[sb]

EBSCO databases keywords

TI ( compliant OR compliance OR comply OR complying OR complied OR complies OR adhere OR adheres OR adhering OR adherent OR adhered OR adherence ) and ( drug OR drugs OR medication* OR pharmacolog* OR Pharmacotherap* OR dose OR doses OR doseage* OR dosage* OR dosing OR dosed OR pill OR pills OR capsule OR capsules OR tablet* OR injection* OR injected OR injects OR injecting ) and TI ( support* OR patient-support OR "pharmacist care" OR "pharmaceutical care" OR program OR intervention* OR pleasant* OR palatab* OR "mobile phone" OR "mobile phones" OR "cellular phone" OR "cellular phones" OR "cell phone" OR "cell phones" OR videophone* OR "text message" OR "text messages" OR "text messaging" OR "text messaged" OR reminder* OR alert OR alerts OR alerting OR alerted OR message* OR (single* AND multiple* ) OR "avoid discontinuation" OR "phone calls" OR "phone call" OR "copayment reduction" OR "copayment reductions" OR "reduced copayments" OR "reduced copayment" OR "cut copayments" OR "copayment cuts" OR "cut copayment" OR "copayment cut" OR "adherence intervention" OR "compliance intervention" OR "adherence interventions" OR "compliance interventions" OR mailing* OR motivational OR "home telemonitoring" OR strategies OR strategy OR (simplif* AND Regimen* ) OR "improving adherence" OR value-based OR "value based" OR "disease management" OR "compliance aid" OR "compliance aids" OR "adherence aid" OR "adherence aids" OR "addressing nonadherence" OR "adressing noncompliance" OR Nudg* OR coach* OR engag* OR DOTS OR "directly observed" OR directly-observed OR "lay health worker" OR "lay health-worker" OR newsletter* OR incentive* OR assistance OR counsel* OR promot* OR SMS OR educat* ) TI ( compliant OR compliance OR comply OR complying OR complied OR complies OR adhere OR adheres OR adhering OR adherent OR adhered OR adherence ) and ( drug OR drugs OR medication* OR pharmacolog* OR Pharmacotherap* OR dose OR doses OR doseage* OR dosage* OR dosing OR dosed OR pill OR pills OR capsule OR capsules OR tablet* OR injection* OR injected OR injects OR injecting ) and TI ( support* OR patient-support OR "pharmacist care" OR "pharmaceutical care" OR program OR intervention* OR p

compliance -- keywords

compliant OR compliance OR  comply OR complying OR complied OR complies OR adhere OR adheres OR adhering OR adherent OR adhered OR adherence OR noncompliant OR noncompliance OR noncomplying  OR non-compliant OR non-compliance OR non-complying  OR nonadhering OR nonadherent OR nonadherence OR non-adhering OR non-adherent OR non-adherence OR (refuse[tiab] AND treatment*[tiab]) OR "refused treatment" OR "refusing treatment" OR "refuses treatment" OR "treatment refusal" OR "refuse treatments" OR "refused treatments" OR "refusing treatments" OR "refuses treatments" OR "decline treatment" OR "declined treatment" OR "declining treatment" OR "declines treatment"  OR "decline treatments" OR "declined treatments" OR "declining treatments" OR "declines treatments" OR "treatment dropout" OR "treatment dropouts" OR "treatment drop-out" OR "treatment drop-outs" OR "directly observed therapy" OR "directly-observed therapy" OR "directly observed treatment" OR "directly-observed treatment" OR (DOTS AND (therapy OR therapies OR treatment* OR pill OR pills OR capsule OR capsules OR injection*OR Injected OR injecting OR inject OR swallowing OR swallowed OR swallows OR swallow))