barriers to clinical trial participation -- keywords and Mesh

The following two PubMed search strategies were designed to be used as part of a two step search for articles focused on barriers to enrolling clinical trial subjects. 


(barrier OR barriers OR obstacle OR obstacles OR impediment OR impediments OR  block OR blocked OR blocking OR blocks OR obstruct OR obstructs OR obstructing OR obstruction OR obstructions OR stop OR stops OR stopping[tiab] OR stopped OR curtail OR curtails OR curtailing OR curtailed OR disinclined OR disinclination OR disinclinations OR object OR objected OR objects OR objecting OR objection OR objections OR barricade OR barricades OR roadblock OR roadblocks OR limit OR limited OR limiting OR limits OR difficulty OR difficulties OR difficult OR bar OR bars OR barred OR barring OR prevent[tiab] OR prevents OR preventing OR interfere OR interferes OR interfering OR interfered OR interference OR glitch OR glitches OR "stumbling block" OR "stumbling blocks" OR hangup OR hangups OR hang-up OR hang-ups OR encumbrance OR encumbrances OR encumber OR encumbers OR encumbering OR encumbered OR hinder OR hindered OR hindering OR hinders OR hindrance OR hindrances OR hold-up OR hold-ups OR "hold up" OR "hold ups" OR snag OR snags OR deterrent OR deterrents OR deter OR deters OR deterred OR deterring OR prohibit[ti] OR prohibits OR prohibiting OR prohibited OR restrict OR restricted OR restricting OR restricts OR restriction OR restrictions OR interdict OR interdicts OR interdicted OR interdiction OR interdictions OR interdicting OR restrain OR restrained OR restraining OR restraint OR restraints OR restrains OR check OR checks OR checked OR checking OR hamper OR hampered OR hampering OR hampers OR unwilling OR willing OR refusal[tiab] OR refuse[tiab] OR refuses[tiab] OR refused OR refusing OR reject OR rejects OR rejected OR rejection OR rejecting OR "decision making"[mesh] OR "Refusal to Participate"[mesh] OR "Communication Barriers"[mesh] OR "patient participation"[mesh]  OR "Research Subjects"[mesh]  OR participate[ti] OR participates[ti] OR participation[ti] OR participating[ti] OR participates[ti] OR enroll[ti] OR enrolls[ti] OR enrolled[ti] OR enrolling[ti] OR enrollee[ti] OR enrollees[ti] OR recruits[ti] OR recruiting[ti] OR recruited[ti] OR recruitment[ti])  AND (participate[ti] OR participates[ti] OR participation[ti] OR participating[ti] OR participates[ti] OR enroll[ti] OR enrolls[ti] OR enrolled[ti] OR enrolling[ti] OR enrollee[ti] OR enrollees[ti] OR subject[ti] OR subjects[ti] OR recruit[ti] OR recruits[ti] OR recruiting[ti] OR recruited[ti] OR recruitment[ti] OR involvement[ti] OR involve[ti] OR involves[ti] OR involved[ti] OR involving[ti] OR involvement[ti] OR join[ti] OR joined[ti] OR joins[ti] OR joining[ti] OR member[ti] OR members OR "Patient selection"[mesh] OR "patient participation"[mesh] OR "Research Subjects"[mesh] OR "Refusal to Participate"[mesh] OR "clinical trials as topic"[MeSH Terms] OR "human experimentation"[mesh]) AND (project OR projects OR program OR programs OR experiment OR experimental OR experiments OR research[tiab] OR intervention[tiab] OR interventions OR trial OR trials[tiab] OR head-to-head OR study OR studies[tiab] OR control[tiab] OR controls OR placebo OR placebos OR randomization OR random OR randomly OR randomisation OR "Refusal to Participate"[mesh]  OR "Research Subjects"[mesh]  OR "clinical trials as topic"[MeSH Terms] OR "human experimentation"[mesh])

(barrier[ti] OR barriers[ti] OR obstacle[ti] OR obstacles[ti] OR impediment[ti] OR impediments[ti] OR  block[ti] OR blocked[ti] OR blocking[ti] OR blocks[ti] OR obstruct[ti] OR obstructs[ti] OR obstructing[ti] OR obstruction[ti] OR obstructions[ti] OR stop[ti] OR stops[ti] OR stopping[ti] OR stopped[ti] OR curtail[ti] OR curtails[ti] OR curtailing[ti] OR curtailed[ti] OR disinclined[ti] OR disinclination[ti] OR disinclinations[ti] OR object[ti] OR objected[ti] OR objects[ti] OR objecting[ti] OR objection[ti] OR objections[ti] OR barricade[ti] OR barricades[ti] OR roadblock[ti] OR roadblocks[ti] OR limit[ti] OR limited[ti] OR limiting[ti] OR limits[ti] OR difficulty[ti] OR difficulties[ti] OR difficult[ti] OR bar[ti] OR bars[ti] OR barred[ti] OR barring[ti] OR prevent[ti] OR prevents[ti] OR preventing[ti] OR interfere[ti] OR interferes[ti] OR interfering[ti] OR interfered[ti] OR interference[ti] OR glitch[ti] OR glitches[ti] OR "stumbling block"[ti] OR "stumbling blocks"[ti] OR hangup[ti] OR hangups[ti] OR hang-up[ti] OR hang-ups[ti] OR encumbrance[ti] OR encumbrances[ti] OR encumber[ti] OR encumbers[ti] OR encumbering[ti] OR encumbered[ti] OR hinder[ti] OR hindered[ti] OR hindering[ti] OR hinders[ti] OR hindrance[ti] OR hindrances[ti] OR hold-up[ti] OR hold-ups[ti] OR "hold up"[ti] OR "hold ups"[ti] OR snag[ti] OR snags[ti] OR deterrent[ti] OR deterrents[ti] OR deter[ti] OR deters[ti] OR deterred[ti] OR deterring[ti] OR prohibit[ti] OR prohibits[ti] OR prohibiting[ti] OR prohibited[ti] OR restrict[ti] OR restricted[ti] OR restricting[ti] OR restricts[ti] OR restriction[ti] OR restrictions[ti] OR interdict[ti] OR interdicts[ti] OR interdicted[ti] OR interdiction[ti] OR interdictions[ti] OR interdicting[ti] OR restrain[ti] OR restrained[ti] OR restraining[ti] OR restraint[ti] OR restraints[ti] OR restrains[ti] OR check[ti] OR checks[ti] OR checked[ti] OR checking[ti] OR hamper[ti] OR hampered[ti] OR hampering[ti] OR hampers[ti] OR unwilling[ti] OR willing[ti] OR refusal[ti] OR refuse[ti] OR refuses[ti] OR refused[ti] OR refusing[ti] OR reject[ti] OR rejects[ti] OR rejected[ti] OR rejection[ti] OR rejecting[ti] OR "decision making"[mesh] OR "Refusal to Participate"[mesh] OR "patient participation"[mesh]  OR "Communication Barriers"[mesh] OR "Research Subjects"[mesh]  OR participate[ti] OR participates[ti] OR participation[ti] OR participating[ti] OR participates[ti] OR enroll[ti] OR enrolls[ti] OR enrolled[ti] OR enrolling[ti] OR enrollee[ti] OR enrollees[ti] OR recruits[ti] OR recruiting[ti] OR recruited[ti] OR recruitment[ti] OR "Research Subjects"[mesh])  AND (participate OR participates OR participation OR participating OR participates OR enroll OR enrolls OR enrolled OR enrolling OR enrollee OR enrollees OR subject OR subjects OR recruit OR recruits OR recruiting OR recruited OR recruitment OR involvement OR involve OR involves OR involved OR involving OR involvement OR join OR joined OR joins OR joining OR member OR members OR "Patient selection"[mesh] OR "patient participation"[mesh] OR "Research Subjects"[mesh] OR "Refusal to Participate"[mesh] OR "clinical trials as topic"[MeSH Terms] OR "human experimentation"[mesh])